That neurotransmitter test looks pretty interesting. Maybe I should get one!
Whenever I hear about low tryptophan issues, I think "pellagra" (intracellular, or systemic), based on studies done 25 years ago. Something (maybe that inflammation) is sucking up all the NAD, which if niacin is insufficient, ends up grabbing the tryptophan (60:1 conversion rate) because NAD is just that important. And the downstream stuff from tryptophan no longer gets produced (serotonin, melatonin).
So the cascade is: low NAD => low TRP => low SRT/MLT => no sleep, not happy. And "brain fog" (pellagra #3: dementia) too.
The study showed that the "pellagra" dropped when cells (and later, patients) were treated with high dose niacinamide.
A NAD precursor might be a band-aid for the tryptophan issue, but getting rid of that underlying cause of inflammation seems best. Interesting how this outcome shows up in that test.
The above University of Pennsylvania study established that spike in the G.I. tract essentially blocked production of tryptophan. Use of 5-HTP employs a different receptor and pathway which results in improved levels of tryptophan and thus serotonin, melatonin, nicotinamide, etc.
An interesting paper. The 5-HTP did seem to help the mice - a different pathway, as you say. And issues with platelets as you said. I'll save this one in my long-covid collection. Not taking in TRP is a bad thing. While waiting to eliminate the gut-covid, it seems like a reasonable band-aid.
I suspect NAD deficiency might also be a thing in long covid too. (A quick search showed a bunch of results). That would also contribute to TRP deficiency indirectly. And TRP (kynurinine) is a very expensive way to make NAD. Niacinamide seems like a low-cost way to avoid any excess TRP consumption. Plus I've got my commission from Big Niacinamide to think about here.
I see and hear of a lot of patients and famiky/friends talk about how they are loosing their memory, brain fog, and some having personality changes- which I have witnessed. They seem to correlate w/post shot/boosters. I on the other hand was never vaxxed but got pretty bad case of delta. I was treated with high doses of Iver (amongst other IV cocktails) which helped…..but I still feel my brain is working differently. And I’m not as sharp. This is almost 4 years later. 😬
This damage was IMO DELIBERATE. THIS is the scariest part to me. The government has huge resources for prooaganda, and talking to people (and witnessing people still wearing masks ALONE and in their car and also walking ALONE) you quickly realize just how successful their campaign of lies were.
People who do not keep reading up on the covid subject are most at risk IMO for the "disinformation".
i hope your friend is taking DHAD HEA (wrong spelling, but the 2 important ingrediants in fish oil. Dr. John Campbell had a interview with another doctor (I think) in the last year and they talked about dementia and how it does not necessarily follow aging, and some things to slow dementia down. People who got the "shots" will have to take more csre of their health than other people.
Ive also heard that regular exercise like walking helps the brain enormously. The brain is nourished by capillaries and exercise helps inprove circulation. I take DMSO, this might help too. Our body cannot break down the white covid clots by itself, but enzymes like nattokinese and others (one is made from pineapple) can help the micro clotting, which in my opinion (uneducated opinion, I have no medical training) contributes to "brain fog".
We cannot trust the government, it should be clear to everyone- and we are going to have to accept responsibilty for this, if we want to get/stay healthy now.
Substack is great for information about what seems to work, and what is probably a waste of time
DHEA/EPA has clear benefit for decreasing inflammation of the endothelium or the cells lining the blood vessels. Part of what I have to consider as a clinician is the pill burden for a patient. And the budget. We have to prioritize the interventions which are gonna make the biggest difference with the smallest pill burden.
Yes to the first, and I'll pass on the second, because it really depends on the individual patient, but we rarely use antibiotics, and most people can't afford HBOT. Honestly, the revelation to us re: CD and Lyme, is that patient's who have come to us for other reasons have shared their personal successes with eradicating Lyme using CD. One extraordinary example is a retired surgeon who struggled with Lyme for twenty years, taking multiple rounds of abx each year. He resolved his Lyme in two months using CDS. Our understanding is that CDS is less effective than CD, in part because CD has some remaining Sodium chlorite, which is an immune modulator. CDS is simply water infused with CD gas, and there is no sodium chlorite left.
Agree with your last sentence. I’ll set aside the rest. There’s the mechanisms of action in theory, and then there is the execution. Clinically, empirically, Bacopa has been invaluable in PASC and vax injury. Knocks spike off nicotinic receptors, increases acetylcholine production in brain and muscles, works as an adaptogen for neurotransmitters, and helps with thyroid. Etc, etc, etc. By this point we’ve used it in thousands of our patients with overall excellent effect.
That neurotransmitter test looks pretty interesting. Maybe I should get one!
Whenever I hear about low tryptophan issues, I think "pellagra" (intracellular, or systemic), based on studies done 25 years ago. Something (maybe that inflammation) is sucking up all the NAD, which if niacin is insufficient, ends up grabbing the tryptophan (60:1 conversion rate) because NAD is just that important. And the downstream stuff from tryptophan no longer gets produced (serotonin, melatonin).
So the cascade is: low NAD => low TRP => low SRT/MLT => no sleep, not happy. And "brain fog" (pellagra #3: dementia) too.
The study showed that the "pellagra" dropped when cells (and later, patients) were treated with high dose niacinamide.
A NAD precursor might be a band-aid for the tryptophan issue, but getting rid of that underlying cause of inflammation seems best. Interesting how this outcome shows up in that test.
The above University of Pennsylvania study established that spike in the G.I. tract essentially blocked production of tryptophan. Use of 5-HTP employs a different receptor and pathway which results in improved levels of tryptophan and thus serotonin, melatonin, nicotinamide, etc.
Nicotinamide is a form of niacin.
An interesting paper. The 5-HTP did seem to help the mice - a different pathway, as you say. And issues with platelets as you said. I'll save this one in my long-covid collection. Not taking in TRP is a bad thing. While waiting to eliminate the gut-covid, it seems like a reasonable band-aid.
I suspect NAD deficiency might also be a thing in long covid too. (A quick search showed a bunch of results). That would also contribute to TRP deficiency indirectly. And TRP (kynurinine) is a very expensive way to make NAD. Niacinamide seems like a low-cost way to avoid any excess TRP consumption. Plus I've got my commission from Big Niacinamide to think about here.
Now how could spike be hiding in the GI tract?
https://elifesciences.org/articles/84790
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
https://pubmed.ncbi.nlm.nih.gov/37848036/
I asked about a friend today who had "long covid". He told me she now has dementia! Is there a connection??
A very strong connection.
I see and hear of a lot of patients and famiky/friends talk about how they are loosing their memory, brain fog, and some having personality changes- which I have witnessed. They seem to correlate w/post shot/boosters. I on the other hand was never vaxxed but got pretty bad case of delta. I was treated with high doses of Iver (amongst other IV cocktails) which helped…..but I still feel my brain is working differently. And I’m not as sharp. This is almost 4 years later. 😬
It’s kind if SCARRY.
Please see my recent Sub about low dose sublingual ketamine.
Thank you!
This damage was IMO DELIBERATE. THIS is the scariest part to me. The government has huge resources for prooaganda, and talking to people (and witnessing people still wearing masks ALONE and in their car and also walking ALONE) you quickly realize just how successful their campaign of lies were.
People who do not keep reading up on the covid subject are most at risk IMO for the "disinformation".
Agreed. It makes me very sad to see people wearing masks when they’re outside walking or in their car by themselves.
i hope your friend is taking DHAD HEA (wrong spelling, but the 2 important ingrediants in fish oil. Dr. John Campbell had a interview with another doctor (I think) in the last year and they talked about dementia and how it does not necessarily follow aging, and some things to slow dementia down. People who got the "shots" will have to take more csre of their health than other people.
Ive also heard that regular exercise like walking helps the brain enormously. The brain is nourished by capillaries and exercise helps inprove circulation. I take DMSO, this might help too. Our body cannot break down the white covid clots by itself, but enzymes like nattokinese and others (one is made from pineapple) can help the micro clotting, which in my opinion (uneducated opinion, I have no medical training) contributes to "brain fog".
We cannot trust the government, it should be clear to everyone- and we are going to have to accept responsibilty for this, if we want to get/stay healthy now.
Substack is great for information about what seems to work, and what is probably a waste of time
DHEA/EPA has clear benefit for decreasing inflammation of the endothelium or the cells lining the blood vessels. Part of what I have to consider as a clinician is the pill burden for a patient. And the budget. We have to prioritize the interventions which are gonna make the biggest difference with the smallest pill burden.
How about she was injured by Both covid And the vax??
Yup
Dies the Leading Edge Clinic treat Lyme disease?
Lyme has not been our focus, but we have treated him Lyme in conjunction with PASC and vaccine injury.
Did you experience success where you did treat? And do you subscribe to the antibiotic, microbial, or oxygen therapy treatments?
Yes to the first, and I'll pass on the second, because it really depends on the individual patient, but we rarely use antibiotics, and most people can't afford HBOT. Honestly, the revelation to us re: CD and Lyme, is that patient's who have come to us for other reasons have shared their personal successes with eradicating Lyme using CD. One extraordinary example is a retired surgeon who struggled with Lyme for twenty years, taking multiple rounds of abx each year. He resolved his Lyme in two months using CDS. Our understanding is that CDS is less effective than CD, in part because CD has some remaining Sodium chlorite, which is an immune modulator. CDS is simply water infused with CD gas, and there is no sodium chlorite left.
Bacopa inhibits PgP 4×, and is a strong inhibitor of many important CYP. Not good....
If taking meds know if the med you take is a substrate of the CYP inhibited by ANY supplement you take.
And how strong the inhibition is.
PGP inhabitation can cause drug toxicity.
Sea Buckhorn has verry little inhibition of pgp, cyp if any, and has many, many benefits.
Just because it's natural doesn't mean it can't hurt you.
Agree with your last sentence. I’ll set aside the rest. There’s the mechanisms of action in theory, and then there is the execution. Clinically, empirically, Bacopa has been invaluable in PASC and vax injury. Knocks spike off nicotinic receptors, increases acetylcholine production in brain and muscles, works as an adaptogen for neurotransmitters, and helps with thyroid. Etc, etc, etc. By this point we’ve used it in thousands of our patients with overall excellent effect.